Antibacterial activity of norfloxacin in the gastrointestinal tracts of rats.
AUTOR(ES)
Frimodt-Møller, P C
RESUMO
The capacities of norfloxacin (MK-0366) and neomycin to reduce the numbers of bacteria in the gastrointestinal tracts of rats were evaluated. Results of a 3-day treatment with norfloxacin were compared with those of a 3-day treatment with neomycin. Both drugs significantly decreased gram-negative and gram-positive bacteria. Norfloxacin effected a significantly greater reduction in numbers of gram-negative bacteria than did neomycin. Norfloxacin also significantly increased the number of anaerobic bacteria. Although neomycin reduced gram-positive bacteria more effectively than did norfloxacin, this difference between the two drugs was not significant. Norfloxacin merits further study for potential as a bowel sterilant.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=185373Documentos Relacionados
- Microbial degradation of oxalate in the gastrointestinal tracts of rats.
- Antibacterial activity of norfloxacin.
- In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.
- In vitro antibacterial activity of norfloxacin (MK-0366).
- Bacterial translocation from the gastrointestinal tracts of rats receiving thermal injury.