Antibacterial activity of trospectomycin (U-63366F) and initial evaluations of disk diffusion susceptibility tests.

AUTOR(ES)

Barry, A L

RESUMO

The in vitro activities of trospectomycin sulfate were compared with those spectinomycin against 632 aerobic microorganisms, including 66 Neisseria gonorrhoeae isolates. Against species other than gram-negative bacilli, trospectomycin was about 4- to 16-fold more active than spectinomycin. For disk diffusion tests, a 30-micrograms disk is recommended, with tentative zone size breakpoints of less than or equal to 13 mm for resistance (MIC, greater than or equal to 64 micrograms/ml) and greater than or equal to 17 mm for susceptibility (MIC, less than or equal to 16 micrograms/ml).

Documentos Relacionados

• In vitro antibacterial activity of trospectomycin (U-63366F), a novel spectinomycin analog.
• Evaluation of Mueller-Hinton agar for disk diffusion susceptibility tests.
• Disk diffusion quality control guidelines for Haemophilus susceptibility tests using cefdinir, CI-960, fleroxacin, temafloxacin, and trospectomycin.
• Evaluation of teicoplanin and vancomycin disk susceptibility tests.
• Activity of pirlimycin against pathogens from cows with mastitis and recommendations for disk diffusion tests.