Antibody Is Required for Protection against Virulent but Not Attenuated Salmonella enterica Serovar Typhimurium

AUTOR(ES)

McSorley, Stephen J.

FONTE

American Society for Microbiology

RESUMO

Resolution of infection with attenuated Salmonella is an active process that requires CD4+ T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28+ CD4+ T cells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4+ T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.

Documentos Relacionados

• SspA Is Required for Lethal Salmonella enterica Serovar Typhimurium Infections in Calves but Is Not Essential for Diarrhea
• A Superoxide-Hypersusceptible Salmonella enterica Serovar Typhimurium Mutant Is Attenuated but Regains Virulence in p47phox−/− Mice
• Vacuole Acidification Is Not Required for Survival of Salmonella enterica Serovar Typhimurium within Cultured Macrophages and Epithelial Cells
• Salmonella enterica Serovar Typhimurium Periplasmic Superoxide Dismutases SodCI and SodCII Are Required for Protection against the Phagocyte Oxidative Burst
• Anti-flagellin antibody responses elicited in mice orally immunized with attenuated Salmonella enterica serovar Typhimurium vaccine strains