Antigen-Presenting Cell Function during Plasmodium yoelii Infection
AUTOR(ES)
Luyendyk, James
FONTE
American Society for Microbiology
RESUMO
Antigen-presenting cells (APC) play a key role in orchestrating immune responses. T-cell proliferative responses are inhibited during the erythrocyte stages of malaria infection, and a number of studies have suggested that APC are responsible for this phenomenon. In the present studies we examine individual components of the T-cell-activating function of APC: expression of costimulatory and major histocompatibility complex (MHC) class II proteins, the ability to process and present antigen to T cells, and the ability to support cytokine production. We find that during the acute phases of Plasmodium yoelii erythrocyte stage infection, APC upregulate the expression of class II MHC and CD80, maintain expression of CD86, process and present antigen, and support gamma interferon production. However the CD11b+ subpopulation produces a soluble factor or factors that specifically inhibit interleukin-2 (IL-2) production by responding CD4 T cells. This factor is distinct from prostaglandin E2, NO, or transforming growth factor β. The data suggest that IL-2 suppression observed during malaria infection is not due to functional defects of APC but is triggered by production of a factor(s) that actively suppresses production of IL-2 by T cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=128011Documentos Relacionados
- Impairment of antigen-presenting cell function by ultraviolet radiation.
- Murine dendritic cell antigen-presenting cell function is not altered by burn injury
- Mycobacterium leprae Infection in Monocyte-Derived Dendritic Cells and Its Influence on Antigen-Presenting Function
- Two genetically identical antigen-presenting cell clones display heterogeneity in antigen processing.
- RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function