Antioncogenic effect of adenovirus E1A in human tumor cells.
AUTOR(ES)
Frisch, S M
RESUMO
Stable expression of the adenovirus 5 E1A gene reduced anchorage-independent growth and tumorigenic potential, caused cytoskeletal reorganization, induced flat morphology, and restored contact inhibition in three human tumor cell lines. By these criteria, E1A appears to be functionally indistinguishable from a tumor suppressor gene in this context. The apparent paradox accorded by the observations of the ability of E1A to transform rodent cells in cooperation with other oncogenes suggests that E1A may be the prototype of a class of growth-regulatory proteins having context-specific transforming and antioncogenic activities.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=52655Documentos Relacionados
- Adenovirus E1A and E1B genes are regulated posttranscriptionally in human lymphoid cells.
- Control functions of adenovirus transformation region E1A gene products in rat and human cells.
- Adenovirus E1A proteins stimulate inositol phospholipid metabolism in PC12 cells.
- Adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells.
- Activation of adenovirus 5 E1A transcription by region E1B in transformed primary rat cells.
