Application of magnetic techniques in the field of drug discovery and biomedicine
AUTOR(ES)
Saiyed, ZM
FONTE
BioMed Central
RESUMO
Magnetic separation technology, using magnetic particles, is quick and easy method for sensitive and reliable capture of specific proteins, genetic material and other biomolecules. The technique offers an advantage in terms of subjecting the analyte to very little mechanical stress compared to other methods. Secondly, these methods are non-laborious, cheap and often highly scalable. Moreover, techniques employing magnetism are more amenable to automation and miniaturization. Now that the human genome is sequenced and about 30,000 genes are annotated, the next step is to identify the function of these individual genes, carrying out genotyping studies for allelic variation and SNP analysis, ultimately leading to identification of novel drug targets. In this post-genomic era, technologies based on magnetic separation are becoming an integral part of todays biology laboratory. This article briefly reviews the selected applications of magnetic separation techniques in the field of biotechnology, biomedicine and drug discovery.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=212320Documentos Relacionados
- In Vivo magnetic resonance techniques and drug discovery
- Histological evaluation of the influence of magnetic field application in autogenous bone grafts in rats
- Study on Application of Static Magnetic Field for Adjuvant Arthritis Rats
- Magnetic Anisotropy and the Orientation of Retinal Rods in a Homogeneous Magnetic Field
- The role of natural products in modern drug discovery.