Application of the Chloro Ketal Claisen Reaction to the Total Synthesis of Squalene*
AUTOR(ES)
Werthemann, Lucius
RESUMO
A short, highly stereoselective (over 97%) synthesis of all-trans squalene is described. Starting with succinaldehyde, a tetraenedichlorodione having the complete squalene skeleton with the four internal trans olefinic bonds has been developed in four steps involving a sequence of two double Claisen rearrangements. Three simple operations convert this intermediate into squalene.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283375Documentos Relacionados
- Application of the Chloro Ketal Claisen Reaction to the Total Synthesis of Squalene. Experimental Details*
- PHOSPHORYLATED INTERMEDIATES IN THE SYNTHESIS OF SQUALENE*
- Unified synthesis of caged Garcinia natural products based on a site-selective Claisen/Diels–Alder/Claisen rearrangement
- Application of base-catalysed reaction to the synthesis of dinucleotides containing the four common deoxyribonucleosides and of oligodeoxythymidylates.
- THE REACTION OF TISSUES TO THE APPLICATION OF RADIUM *
