Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.
AUTOR(ES)
Meshnick, S R
RESUMO
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=239445Documentos Relacionados
- Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.
- Antimalarial chemotherapy. Mechanisms of action, resistance, and new directions in drug discovery
- Iron-dependent free radical generation from the antimalarial agent artemisinin (qinghaosu).
- The population dynamics of antimicrobial chemotherapy.
- Mastectomy following preoperative chemotherapy.