Aryl Hydrocarbon Hydroxylase and Polycyclic Hydrocarbon Tumorigenesis: Effect of the Enzyme Inhibitor 7,8-Benzoflavone on Tumorigenesis and Macromolecule Binding
AUTOR(ES)
Kinoshita, Nadao
RESUMO
Aryl hydrocarbon hydroxylase is present and is inducible in mouse skin. 7,8-Benzoflavone, an inhibitor of the enzyme, markedly inhibits tumorigenesis by 7,12-dimethylbenz(a)anthracene, but has either no effect on or stimulates benzo(a)pyrene tumorigenesis. Thus, the role of aryl hydrocarbon hydroxylase appears highly specific for each polycyclic hydrocarbon, in respect to detoxification and/or activation of the hydrocarbon to a carcinogenic form. In parallel studies, we found that 7,8-benzoflavone significantly reduces the amount of 7,12-dimethylbenz(a)anthracene binding to mouse skin DNA, RNA, and protein, and the binding of benzo(a)pyrene to RNA and protein of mouse skin. 7,8-Benzoflavone exhibited a markedly lesser effect on the binding of benzo(a)pyrene to DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=426573Documentos Relacionados
- Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione*
- Human Skin Aryl Hydrocarbon Hydroxylase: INDUCTION BY COAL TAR
- Stimulation of Aryl Hydrocarbon Hydroxylase Induction in Cell Cultures by Interferon
- Comparison of Aryl Hydrocarbon Hydroxylase Induction in Cultured Blood Lymphocytes and Pulmonary Macrophages
- Regulation of Aryl Hydrocarbon Hydroxylase in Intraspecific Hybrids of Human, Mouse, and Hamster Cells
