"Avaliação da osteogênese com proteínas ósseas morfogenéticas (BMPs): análise em defeitos na calvária e ao redor de implantes de titânio em coelhos". / Osseointegration enhancement around titanium implants and calvarial reconstruction induced by bone morphogenetic proteins in rabbits

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

Objective. Study I:The aim of this study was to assess osteogenesis in cirurgically created skull defects in rabbits (Oryctolagus cuniculus) induced by bone morphogenetic proteins combined to the composite calcium carboante-collagen. Study II: Avaliate osteogenesis around titanium implants inserted in the rabbit tibia, induced by bone morphogenetic protein combined to the composite calcium carbonate-collagen. The parameters assessed were boneimplant interface and the bone volume between threads of titanium. Material and methods. Study I: Skull defects were cirurgically created in 45 New Zealand male white rabbits. Test sites were filled with 1,0mg of reindeer (Rangifer tarandus) rBMP combined to the composite calcium carbonate-collagen. Control sites received either autogenous bone (positive control), composite calcium carbonate-collagen or left untreated (negative control). Study II: Sixty titanium implants were inserted in the tíbia of 30 New Zealand male white rabbits. Previously to its insertion, teste sites were filled with 1,0mg of rBMP combined to the composite calcium carbonate-collagen. Control sites were filled either with composite calcium carbonatecollagen, collagen or left untreated. Results. Rabbits were submitted to euthanasia 4, 6 and 10 weeks after implantation. Study I: Histometric and tomographic analysis were perfomed. rBMP-calcium carbonate-collagen treated sites showed earlier and increased osteogenesis compared to control sites and similar results to autogenous bone. Tomographic scans showed similar pattern to histomorphometry, although overestimated for the composite groups at 4 and 6 weeks examination periods. Study II: Histometric analysis was performed. Test sites showed a percent linear bone-implant contact and percent bone volume at implant threads greater for all periods of examination than control sites. Conclusion: The results demonstrated that 1,0mg of rBMP combined to calcium carbonate-collagen composite were able enhance osteogenesis at orthotopic sites. Association of graft materials combined to rBMP increases quality at bone- implant interface Though the time between surgical implant placement and prosthetic rehabilitation at sites with large medular spaces and less cortical bone could be shortened.

ASSUNTO(S)

osteogênese proteínas

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