Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa

AUTOR(ES)

Tateda, Kazuhiro

FONTE

American Society for Microbiology

RESUMO

We report that 2 μg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

Documentos Relacionados

• Vfr controls quorum sensing in Pseudomonas aeruginosa.
• The Pseudomonas Quinolone Signal Regulates rhl Quorum Sensing in Pseudomonas aeruginosa
• Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa.
• Regulation of Quorum Sensing by RpoS in Pseudomonas aeruginosa
• Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa