B-cell function in vitro during rubella infection.

AUTOR(ES)

Hyypiä, T

RESUMO

B-cell function in vitro was studied in patients with natural rubella virus infection. Lymphocyte responses to mitogens in a blast transformation test were decreased at the onset of the rash. Spontaneous immunoglobulin production by peripheral blood lymphocytes was increased during the acute phase of illness. In regulatory T-cell subpopulations, increased proportions of cells with suppressor/cytotoxic phenotypes and decreased proportions of cells with helper/inducer phenotypes were detected simultaneously with the increased spontaneous immunoglobulin production. All parameters studied were recovered during the convalescent phase.

Documentos Relacionados

• In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis
• Role of ζPKC in B-cell signaling and function
• Characterization of B-cell epitopes on IpaB, an invasion-associated antigen of Shigella flexneri: identification of an immunodominant domain recognized during natural infection.
• Single cell studies on the role of B-cell stimulatory factor 1 in B-cell activation.
• Overexpression of Fc receptor-like 1 associated with B-cell activation during hepatitis B virus infection