B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells.
AUTOR(ES)
Weiss, S
RESUMO
Antigen-presenting B-lymphoma cells were transfected with the gene encoding the immunoglobulin lambda 2 light chain of MOPC315 cells (lambda 2(315). The lambda 2 chain is expressed on the cell surface of the transfectants together with the endogenous heavy chain. The transfectants present an idiotope of the lambda 2(315) light chain to class II-restricted T-cell clones. Recognition by the T cells requires processing of the lambda 2(315) light chain. From these data we conclude that B-lymphoma cells constitutively process and present their immunoglobulins. Secretion and reuptake of the light chain was not necessary for the presentation. Thus, B cells bear two types of idiotypes on their membrane, a native form as surface immunoglobulin and a processed form in the context of products of the major histocompatibility complex.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=286448Documentos Relacionados
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