B-raf, a new member of the raf family, is activated by DNA rearrangement.

AUTOR(ES)

Ikawa, S

RESUMO

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

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