Bacterial autoinduction: looking outside the cell for new metabolic engineering targets

AUTOR(ES)

DeLisa, Matthew P

FONTE

BioMed Central

RESUMO

Recent evidence has demonstrated that cell-to-cell signaling is a fundamental activity carried out by numerous microorganisms. A number of specialized processes are reported to be regulated by density-dependent signaling molecules including antibiotic production, bioluminescence, biofilm formation, genetic competence, sporulation, swarming motility and virulence. However, a more centralized role for quorum sensing is emerging where quorum signaling pathways overlap with stress and starvation circuits to regulate cellular adaptation to changing environmental conditions. The interplay of these phenomena is especially critical in the expression of recombinant proteins where elicitation of stress responses can dramatically impact cellular productivity.

Documentos Relacionados

• Alkaloid Biosynthesis[mdash]The Basis for Metabolic Engineering of Medicinal Plants.
• On the Outside Looking In: Promoting HIV/AIDS Research Initiated by African American Investigators
• Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis
• Antisense RNA Strategies for Metabolic Engineering of Clostridium acetobutylicum
• The World Trade Center Attack: Eye witness: observations of a physician on the outside looking in