Bacterial Superantigen Exposure after Resolution of Influenza Virus Infection Perturbs the Virus-Specific Memory CD8+-T-Cell Repertoire

AUTOR(ES)

Huang, Chiu-Chen

FONTE

American Society for Microbiology

RESUMO

Heterologous viral infections have been shown to impact the preexisting memory CD8+-T-cell repertoire. Bacterial superantigens are products of common human pathogenic bacteria, including staphylococci and streptococci, that are potent T-cell-stimulatory molecules. In this report, we show that exposure to staphylococcal enterotoxin B, a bacterial superantigen, causes a selective functional deletion of cross-reactive influenza virus-specific CD8+ memory T cells. This perturbation of the memory repertoire can have a significant impact on viral clearance after secondary challenge.

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