Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
AUTOR(ES)
Holland, Eric C.
FONTE
National Academy of Sciences
RESUMO
Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer in transgenic mice. A transgene encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific glial fibrillary acidic protein promoter permits efficient glia-specific transfer of genes carried by subgroup A avian leukosis virus vectors. With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=18724Documentos Relacionados
- Carbonic anhydrase C in the neural retina: transition from generalized to glia-specific cell localization during embryonic development.
- Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene.
- Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.
- The POU domain protein Tst-1 and papovaviral large tumor antigen function synergistically to stimulate glia-specific gene expression of JC virus.
- Basic fibroblast growth factor induces angiogenesis in vitro.