Bayesian analysis of gene expression levels: statistical quantification of relative mRNA level across multiple strains or treatments

AUTOR(ES)

Townsend, Jeffrey P

FONTE

BioMed Central

RESUMO

Many methodologies of microarray analysis discard the quantitative results inherent in cDNA microarray comparisons or cannot be flexibly applied to multifactorial experimental design. A quantitative Bayesian framework is presented that can be used to analyze normalized microarray data in which any number of treatments, genotypes, or developmental states are studied using a continuous chain of comparisons.

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