Beta-Indoleethanol and Beta-Indolelactic Acid Production by Candida Species: Their Antibacterial and Autoantibiotic Action

AUTOR(ES)

Narayanan, T. K.

RESUMO

Candida spp. grown in synthetic medium supplemented with l-tryptophan as sole nitrogen source produced β-indoleethanol (β-IEA) and β-indolelactic acid (β-ILA). These compounds isolated from the culture filtrates were characterized by ultraviolet, infrared, and nuclear magnetic resonance spectral studies. Using dl-[3H]trypotophan in the medium, labeled β-IEA and β-ILA were isolated. Further, β-IEA was produced as a result incubating log-phase cells of C. albicans with β-ILA. Both β-IEA and β-ILA inhibited the growth of gram-positive and -negative bacteria. Autoantibiotic action of these compounds on Candida spp. and the reversal of this inhibition were studied.

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