Bidirectional Concentration-Dependent Effects of Tumor Necrosis Factor Alpha in Shigella dysenteriae-Related Seizures
AUTOR(ES)
Yuhas, Yael
FONTE
American Society for Microbiology
RESUMO
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-α) was proconvulsive in this respect. The present study shows that TNF-α, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-α may play a protective role in neurologic complications of S. dysenteriae infection.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=152059Documentos Relacionados
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