Binding of autologous erythrocytes to immature T-cells.
AUTOR(ES)
Charreire, J
RESUMO
A small percentage of normal mouse thymus and spleen lymphocytes form rosettes with autologous erythrocytes. The number of these autologous rosettes increases 15- to 20-fold after adult thymectomy and to a lesser degree with aging. Autologous rosette level is also abnormally high in nude (congenitally athymic) mice. The high level of autologous rosette-forming cells found after adult thymectomy is normalized by injecting ng amounts of purified circulating thymic factor. Autologous rosette-forming cells adhere to nylon, belong to the less dense spleen cells, are in majority steroid-resistant in the thymus. All these properties suggest that autologous rosette-forming cells might belong to immature T-cell (thymic-dependent cell) precursors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=432950Documentos Relacionados
- Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.
- The cytoplasmic domain of CD4 plays a critical role during the early stages of HIV infection in T-cells.
- The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.
- Human thymic epithelial cells directly induce activation of autologous immature thymocytes.
- THE RESISTANCE OF IMMATURE ERYTHROCYTES TO HEAT *