Binding of resting platelets to Candida albicans germ tubes.

AUTOR(ES)

Robert, R

RESUMO

The binding of resting platelets to Candida albicans germ tubes was studied by means of an affinity column in which germ tubes were physically immobilized. Adhesion of platelets to the column was dependent on both the germ tube concentration and the number of platelets applied. It was found that the interaction of C. albicans germ tubes with platelets is specific and should be mediated by a fungal protein receptor. The results obtained by scanning electron microscopy confirmed that resting platelets can fix directly onto germ tubes. In addition, this study showed that attachment of platelets onto C. albicans is associated with morphological changes. Platelets lost their discoid shape, became globular, generated spikes or pseudopods, and then flattened on the yeast cells.

Documentos Relacionados

• Laminin receptors on Candida albicans germ tubes.
• Simplified adsorption method for detection of antibodies to Candida albicans germ tubes.
• Demonstration and solubilization of antigens expressed primarily on the surfaces of Candida albicans germ tubes.
• Detection of Antibodies to Candida albicans Germ Tubes during Experimental Infections by Different Candida Species
• Germ Tubes and Proteinase Activity Contribute to Virulence of Candida albicans in Murine Peritonitis