Bioassay-guided evaluation of central nervous system effects of citronellal in rodents

AUTOR(ES)

Melo, Mônica S., Santana, Marilia T. de, Guimarães, Adriana G., Siqueira, Rosana S., Sousa, Damião P. De, Santos, R. V., Bonjardim, Leonardo R., Araújo, Adriano A. S., Onofre, Alexandre S. C., Lima, Julianeli T., Almeida, Jackson R. G. S., Quintans-Júnior, Lucindo J.

FONTE

Revista Brasileira de Farmacognosia

DATA DE PUBLICAÇÃO

08/07/2011

RESUMO

The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABA A receptor. These results suggest a possible CNS depressant and anticonvulsant activities.

Documentos Relacionados

• Bioassay-guided evaluation of wound healing effect of fatty acids-incorporated collagen-based films
• Bioassay-guided fractionation and antimicrobial and cytotoxic activities of Cassia bakeriana extracts
• Evaluation of central nervous system effects of Citrus limon essential oil in mice
• Effects of growth hormone in the central nervous system
• Triagem da atividade antioxidante e anticolinesterásica de extratos naturais: seleção e estudo químico biomonitorado de Streptomyces sp. e de Psychotria carthagenensis