Biochemical and immunological properties of two forms of pertactin, the 69,000-molecular-weight outer membrane protein of Bordetella pertussis.
AUTOR(ES)
Gotto, J W
RESUMO
Two apparent isoforms of the virulence-associated 69,000-molecular-weight protein pertactin were purified from Bordetella pertussis. Mass spectrometry showed a difference of 2,060 Da, which may result from differential C-terminal cleavage of a larger precursor. Both forms were protective in a mouse model, eliciting bactericidal antibodies and reducing respiratory tract colonization.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=280825Documentos Relacionados
- Molecular cloning and characterization of protective outer membrane protein P.69 from Bordetella pertussis.
- Epitope Structure of the Bordetella pertussis Protein P.69 Pertactin, a Major Vaccine Component and Protective Antigen
- Adenylate cyclase activity of a 68,000-molecular-weight protein isolated from the outer membrane of Bordetella bronchiseptica.
- The conserved 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi has homology to PAL.
- Serum antibody responses to the outer membrane proteins of Bordetella pertussis.
