Biological Characterization of Rev Variation in Equine Infectious Anemia Virus
AUTOR(ES)
Belshan, Michael
FONTE
American Society for Microbiology
RESUMO
Sequence analysis identified significant variation in the second exon of equine infectious anemia virus (EIAV) rev. Functional analysis indicated that limited amino acid variation in Rev significantly altered the export activity of the protein but did not affect Rev-dependent alternative splicing. EIAV Rev can mediate export through two independent cis-acting Rev-responsive elements (RREs), and differences among Rev variants were more pronounced when both RREs were present. Variation in Rev may be an important mechanism for regulation of virus replication in vivo and may contribute to changes in clinical disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=109674Documentos Relacionados
- Structural and functional characterization of rev-like transcripts of equine infectious anemia virus.
- Identification of the activation domain of equine infectious anemia virus rev.
- Cloning and characterization of cDNAs encoding equine infectious anemia virus tat and putative Rev proteins.
- Subpopulations of Equine Infectious Anemia Virus Rev Coexist In Vivo and Differ in Phenotype
- Characterization of RNA from equine infectious anemia virus.