Block of some non-adrenergic inhibitory responses of smooth muscle by a substance from haemolysed erythrocytes

AUTOR(ES)

Bowman, Anne

RESUMO

1. A preparation of haemolysed rat erythrocytes (the haemolysate) blocked the relaxations of both the bovine retractor penis and the rat anococcygeus muscles in response to field stimulation of their non-adrenergic inhibitory nerves. The effective concentration range was 5-20 μl./ml. of haemolysate, equivalent to 0·25-1·0 μl./ml. of blood. The active principle in the haemolysate was a non-dialysable, heat-labile material of molecular weight between 50,000 and 100,000 daltons. If, as appeared probable, the active component of the haemolysate was oxyhaemoglobin, its effective blocking concentration was 0·5-2 μM.

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