Bordetella pertussis-induced Alteration of the Normal Hyperglycemic Response of Mice to 3′,5′-Adenosine Phosphate

AUTOR(ES)

Cronholm, Lois S.

RESUMO

Blockade of the adrenergic receptors or the injection of Bordetella pertussis vaccine prevented the normal hyperglycemic response of CFW mice to exogenous cyclic 3′,5′-adenosine phosphate (3′,5′-AMP). The cyclic nucleotide was also ineffective in offsetting the histamine hypersensitivity of the β-adrenergically blocked and the pertussis-sensitized groups. These observations suggest that the autonomic malfunction occurs at a point(s) subsequent to release of 3′,5′-AMP. Neither the hyperglycemic effect of epinephrine or 3′,5′-AMP, or both, nor the histamine sensitivity of pertussis-pretreated animals was influenced by the subcutaneous administration of theophylline.

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