Brønsted Acid-Catalyzed Dipeptides Functionalization through Azlactones

AUTOR(ES)

Santos, Igor F. dos, Castro, Pedro P. de, Almeida, Angelina M. de, Amarante, Giovanni W.

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2017-07

RESUMO

Azlactones are useful building blocks in the synthesis of functional amino acid derivatives, heterocycles and bioactive molecules. In this work, a protocol for the organocatalytic functionalization of dipeptides has been presented. 2-Alkyl-substituted azlactone intermediates in the presence of different amines and alcohols were combined in a ring opening reaction approach. The products were synthesized in moderate to excellent isolated yields, providing new insights in peptide transformations involving carbodiimide activation.

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