Ca ions stabilize the binding of complement factor iC3b to the pseudohyphal form of Candida albicans.
AUTOR(ES)
Spötl, L
RESUMO
The pseudohyphal form of Candida albicans is able to bind iC3b. This may play an important role in the pathogenesis of disseminated candidiasis and, in particular, in adherence to endothelium, protection against complement action, and iron acquisition from erythrocytes. Here we report that Ca2+ ions are required to maintain stable binding of iC3b to C. albicans pseudohyphae.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=186233Documentos Relacionados
- Isolation and biochemical characterization of the iC3b receptor of Candida albicans.
- Reduced expression of the functionally active complement receptor for iC3b but not for C3d on an avirulent mutant of Candida albicans.
- Cleavage of Complement C3b to iC3b on the Surface of Staphylococcus aureus Is Mediated by Serum Complement Factor I
- Candida albicans and Candida stellatoidea, in contrast to other Candida species, bind iC3b and C3d but not C3b.
- Activation of the complement system by Cryptococcus neoformans leads to binding of iC3b to the yeast.
