Campylobacter jejuni from Patients with Guillain-Barré Syndrome Preferentially Expresses a GD1a-Like Epitope

AUTOR(ES)

Nachamkin, Irving

FONTE

American Society for Microbiology

RESUMO

GM1- and GD1a-like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD1a-like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD1a-like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.

Documentos Relacionados

• Lipopolysaccharides from Campylobacter jejuni associated with Guillain-Barré syndrome patients mimic human gangliosides in structure.
• Guillain–Barré syndrome with antibodies to GD1a/GD1b complex
• Campylobacter Species and Guillain-Barré Syndrome
• Molecular Characterization of Campylobacter jejuni from Patients with Guillain-Barré and Miller Fisher Syndromes
• Flagella as a Potential Marker for Campylobacter jejuni Strains Associated with Guillain-Barré Syndrome