CD46 short consensus repeats III and IV enhance measles virus binding but impair soluble hemagglutinin binding.
AUTOR(ES)
Devaux, P
RESUMO
The binding of a recombinant soluble form of the measles virus (MV) hemagglutinin (sH) to cells expressing hybrid CD46/CD4 proteins was compared to that of purified virus. For binding of both ligands, both CD46 external short consensus repeats I and II (SCR I and II) in the natural order were essential. The addition of SCR III and IV enhanced virus binding but inhibited sH binding. Accordingly, this lowered the ability of sH to compete with MV binding. Antihemagglutinin monoclonal antibodies selectively inhibited the binding of either sH or MV. Thus, sH and MV share a common binding site in SCR I and II but differ in their apparent avidity to CD46 under the influence of SCR III and IV.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=191575Documentos Relacionados
- Octamerization Enables Soluble CD46 Receptor To Neutralize Measles Virus In Vitro and In Vivo
- Antibody cross-reactivity with CD46 and lack of cell surface expression suggest that moesin might not mediate measles virus binding.
- Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding.
- Differential downregulation of CD46 by measles virus strains.
- Productive Measles Virus Brain Infection and Apoptosis in CD46 Transgenic Mice