Cefuroxime, a Beta-Lactamase-Resistant Cephalosporin with a Broad Spectrum of Gram-Positive and -Negative Activity
AUTOR(ES)
Neu, Harold C.
RESUMO
The in vitro activity of cefuroxime, a cephalosporin antibiotic, was investigated against 604 isolates and compared with the activity of other β-lactam compounds. Cefuroxime had activity comparable to that of other cephalosporins, including cefamandole and cefoxitin, against streptococcal and staphylococcal species; most streptococci were inhibited by 0.1 μg or less per ml, and staphylococci were inhibited by 1.6 μg or less per ml. Enterococci were relatively resistant. Cefuroxime inhibited β-lactamase-producing Neisseria gonorrhoeae and Haemophilus influenzae. Cefuroxime had excellent activity against members of the Enterobacteriaceae; 83% of β-lactamase-producing Escherichea coli, 100% of Salmonella, 100% of Klebsiella, 90% of Proteus mirabilis, 95% of Citrobacter, 56% of Enterobacter, and 58% of Shigella were inhibited by 12.5 μg/ml. Cefuroxime had activity comparable to that of cefamandole and cefoxitin; it inhibited isolates of E. coli and Klebsiella resistant to cefamandole and inhibited Enterobacter and Citrobacter resistant to cefoxitin. Many isolates of Serratia, some indole-positive strains of Proteus, and Bacteroides fragilis were resistant to cefuroxime. Resistance of cefuroxime to hydrolysis by β-lactamases played a major role in its activity against both gram-positive and gram-negative organisms.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352306Documentos Relacionados
- Postantibiotic Effects of Gatifloxacin against Gram-Positive and -Negative Organisms
- Postantibiotic Effect of Trovafloxacin against Gram-Positive and -Negative Organisms
- Comparative Activities of Clinafloxacin against Gram-Positive and -Negative Bacteria
- Interaction of a New Cephalosporin, 7-Cyanacetamidocephalosporanic Acid, with Some Gram-Negative and Gram-Positive β-Lactamase-Producing Bacteria
- Resistance of Pseudomonas aeruginosa to new beta-lactamase-resistant beta-lactams.