Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
AUTOR(ES)
Aarvak, Tanja
FONTE
BioMed Central
RESUMO
The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs and T cells are essential for the initiation and amplification of T-cell-dependent immune responses, and may therefore play an important role in the chronic inflammatory processes in the synovium. The nature of the antigen(s) involved in RA still remains elusive. However, interactions and signaling through the costimulatory molecules CD28-CD80/86 and CD40-CD40L are critical during APC–T cell interaction for optimal cell activation. This review discusses how such costimulatory signals can be involved in the initiation and amplification of the inflammatory reactions in the synovium. Blocking of the signaling pathways involved in APC–T cell interactions might provide a specific immuno-therapeutic approach for the treatment of RA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=128879Documentos Relacionados
- Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis
- Cell-cell interactions in synovitis: Interactions between T lymphocytes and synovial cells
- Cell-cell interactions in synovitis: Endothelial cells and immune cell migration
- Cell–cell interaction in prostate gene regulation and cytodifferentiation
- Organization and Cell-Cell Interaction in Starved Saccharomyces cerevisiae Colonies