Cell Wall Component Which Affects the Ability of Serum to Promote Phagocytosis and Killing of Staphylococcus aureus
AUTOR(ES)
Shayegani, Mehdi
RESUMO
The role of various cell wall components of nonencapsulated Staphylococcus aureus in phagocytosis and killing was studied. Adsorption of human serum with S. aureus cell walls, or trypsin-digested cell walls, reduced the rate of phagocytosis and killing of S. aureus by human-blood leukocytes when compared to unadsorbed serum. When the various components of the cell walls were used for adsorption, only the intact mucopeptide was found to remove these factors. Products of digestion of this mucopeptide with several enzymes were found to be inactive when used for adsorption of human serum. Other components tested were teichoic acids α, β, and combinations of both and protein A. When used in equivalent amounts, these were found to have no effect on the removal of serum factors necessary for phagocytosis and intracellular killing of S. aureus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=416086Documentos Relacionados
- Localization of the third component of complement on the cell wall of encapsulated Staphylococcus aureus M: implications for the mechanism of resistance to phagocytosis.
- Ability of Staphylococcus aureus coagulase genotypes to resist neutrophil bactericidal activity and phagocytosis.
- Enhanced phagocytosis, killing, and serum sensitivity of Escherichia coli and Staphylococcus aureus treated with sub-MICs of imipenem.
- Phagocytosis and intracellular killing of Staphylococcus aureus by normal mouse peritoneal macrophages.
- Phagocytosis and killing of Staphylococcus aureus: effects of stress and depression in children.