Cephalexin: Absorption and Excretion as Related to Renal Function and Hemodialysis

AUTOR(ES)

Reisberg, Boris E.

RESUMO

Cephalexin is a new semisynthetic cephalosporin C derivative, which is well absorbed from the gastrointestinal tract and excreted in high concentration in the urine. Even in patients with impaired renal function, the concentrations of cephalexin present in the urine are adequate for the treatment of most urinary tract infections produced by Escherichia coli, Klebsiella, and Proteus mirabilis. In anephric patients, single doses of 250 or 500 mg of cephalexin resulted in high, prolonged serum concentrations. Peak levels were usually observed within 1 hr. However, in two of six anephric patients, peak levels were reached after 6 and 12 hr due to delayed absorption. Hemodialysis for 6 hr reduced the serum concentration of cephalexin by 58%.

Documentos Relacionados

• Pharmacokinetics of Cefaclor and Cephalexin: Dosage Nomograms for Impaired Renal Function
• Cephalexin and Cephaloglycin Activity In Vitro and Absorption and Urinary Excretion of Single Oral Doses in Normal Young Adults
• THE EXCRETION OF XYLOSE AS AN INDEX OF DAMAGED RENAL FUNCTION
• RENAL FUNCTION AS A FACTOR IN THE URINARY EXCRETION OF ASCORBIC ACID
• Jejunal Absorption and Secretion of Calcium in Patients with Chronic Renal Disease on Hemodialysis