Characterization of a cDNA clone encoding the visna virus transactivating protein.

AUTOR(ES)

Davis, J L

RESUMO

The unique pathogenesis of lentiviral infections in humans and ruminant animals may be explained, in part, by the complex mechanisms regulating transcription and translation of their viral genes. This report demonstrates that a visna virus-encoded protein transactivates viral gene expression. A 1.4-kilobase cDNA clone encodes two distinct proteins with apparent molecular masses of 21.5 and 10 kDa. We demonstrate that the 10-kDa species is the visna virus transactivating (Tat) protein; the other species may be analogous to the rev (formerly art or trs) gene product of human immunodeficiency virus.

Documentos Relacionados

• The nucleotide sequence of a cDNA clone encoding the wheat Em protein.
• A wheat (Triticum aestivum) cDNA clone encoding a plastid-localized heat-shock protein.
• An Arabidopsis thaliana cDNA clone encoding a low molecular weight heat shock protein.
• A cDNA clone from Pisum sativum encoding a low molecular weight heat shock protein.
• Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein.