Characterization of an Anticryptococcal Protein Isolated from Human Serum

AUTOR(ES)

Sridhar, Sridevi

FONTE

American Society for Microbiology

RESUMO

Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of ∼81.8 kDa, a pI of ∼6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity and that of apotransferrin and 5% human serum were reversed by 10 μM freshly prepared FeCl3.

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