Chemical synaptic activity modulates nearby electrical synapses
AUTOR(ES)
Smith, Mackenzie
FONTE
The National Academy of Sciences
RESUMO
Most electrically coupled neurons also receive numerous chemical synaptic inputs. Whereas chemical synapses are known to be highly dynamic, gap junction-mediated electrical transmission often is considered to be less modifiable and variable. By using simultaneous pre- and postsynaptic recordings, we demonstrate at single mixed electrical and chemical synapses that fast chemical transmission interacts with gap junctions within the same ending to regulate their conductance. Such localized interaction is activity-dependent and could account for the large variation in strength of electrical coupling at auditory afferent synapses terminating on the Mauthner cell lateral dendrite. Thus, interactions between chemical and electrical synapses can regulate the degree of electrical coupling, making it possible for a given neuron to independently modify coupling at different electrical synapses with its neighbors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=153644Documentos Relacionados
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