Chemotaxis inhibition by Gardnerella vaginalis and succinate producing vaginal anaerobes: composition of vaginal discharge associated with G vaginalis.
AUTOR(ES)
Sturm, A W
RESUMO
The influence of six succinate producing vaginal anaerobes and Gardnerella vaginalis on the chemotactic activity of granulocytes was studied by the under agarose method. G vaginalis, Mobiluncus species, and three Gram negative anaerobes elicited hardly any response, but Peptostreptococcus productus showed clear positive chemotaxis, as did the Escherichia coli strain used as a control. Inhibition of the chemotactic response of white blood cells was found with all strains, but the high succinate producers from the genus Bacteroides showed the most pronounced effect. The inhibition of chemotaxis by succinate producing anaerobes in the pathogenesis of non-specific vaginitis (NSV) is postulated, and B ureolyticus or Mobiluncus spp, rather than G vaginalis, are suggested as possible causes of NSV.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1194299Documentos Relacionados
- Biotypes of Gardnerella vaginalis.
- Two Novel Vaginal Microbicides (Polystyrene Sulfonate and Cellulose Sulfate) Inhibit Gardnerella vaginalis and Anaerobes Commonly Associated with Bacterial Vaginosis
- Antimicrobial susceptibilities of Gardnerella vaginalis.
- First isolation of Gardnerella vaginalis.
- Identification of Gardnerella (Haemophilus) vaginalis.