Chemotherapy of Experimental Streptococcal Endocarditis: II. SYNERGISM BETWEEN PENICILLIN AND STREPTOMYCIN AGAINST PENICILLIN-SENSITIVE STREPTOCOCCI
AUTOR(ES)
Durack, David T.
RESUMO
Bacterial endocarditis was produced by intravenous injection of Streptococcus viridans into rabbits with preexisting sterile endocardial vegetations. After 6 h had elapsed, bacteria in the vegetations could not be eradicated by brief treatment with antimicrobials to which the streptococci were sensitive. However, when treatment with penicillin was continued for 4 days, the animals were cured. The 6-h infection therefore offered a model in which treatments could be conveniently compared over a short period. Synergism was demonstrated between penicillin and streptomycin in endocarditis due to a fully penicillin-sensitive streptococcus, a point which had not been previously proved in vivo. The clinical implications are discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=333064Documentos Relacionados
- Penicillin-sensitive Moraxella prosthetic endocarditis. Near disaster caused by failure to treat with penicillin.
- Overuse of health resources by penicillin-sensitive children.
- Activities of Ertapenem, a New Long-Acting Carbapenem, against Penicillin-Sensitive or -Resistant Pneumococci in Experimental Meningitis
- Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.
- Glycopeptide transpeptidase and D-alanine carboxypeptidase: penicillin-sensitive enzymatic reactions.
