Chemotherapy of experimental streptococcal endocarditis: Part III Failure of a bacteriostatic agent (tetracycline) in prophylaxis 1

AUTOR(ES)

Southwick, Frederick S.

RESUMO

Bacteriostatic agents are frequently recommended as alternatives to penicillin for prophylaxis of bacterial endocarditis. To test the efficacy of this group of antimicrobials, prophylaxis of experimental streptococcal endocarditis was attempted with tetracycline. The number of streptococci colonizing the aortic valves of rabbits was not affected by inhibitory levels of tetracycline, but multiplication was checked. Streptococcis urvived in vegetations for seven days despite the continuous presence of tetracycline, and multiplied when the drug was withdrawn. It is therefore suggested that bacteriostatic agents may be valueless for prophylaxis of bacterial endocarditis.

Documentos Relacionados

• Chemotherapy of experimental streptococcal endocarditis. IV. Further observations on prophylaxis.
• Chemotherapy of Experimental Streptococcal Endocarditis: II. SYNERGISM BETWEEN PENICILLIN AND STREPTOMYCIN AGAINST PENICILLIN-SENSITIVE STREPTOCOCCI
• Failure of prophylaxis for bacterial endocarditis: American Heart Association Registry.
• Experimental endocarditis: prophylaxis of Candida albicans infections by 5-fluorocytosine in rabbits.
• Successful Trovafloxacin Prophylaxis against Experimental Streptococcal Aortic Valve Endocarditis