Chlamydia trachomatis Infection Inhibits Both Bax and Bak Activation Induced by Staurosporine

AUTOR(ES)

Xiao, Yangming

FONTE

American Society for Microbiology

RESUMO

We have previously shown that Chlamydia trachomatis inhibits host cell apoptosis and blocks mitochondrial cytochrome c release. We now report that activation of both Bax and Bak, two proapoptotic members of the Bcl-2 family that regulate mitochondrial cytochrome c release, was inhibited in chlamydia-infected cells. This observation has provided new information on the mechanisms of chlamydial antiapoptotic activity.

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