Chloramphenicol, gentamicin, and ciprofloxacin against murine scrub typhus.
AUTOR(ES)
McClain, J B
RESUMO
Ciprofloxacin (120 mg/kg of body weight per day), chloramphenicol (300 mg/kg per day), and gentamicin (30 mg/kg per day) were compared with placebo in a BALB/cj mouse model of scrub typhus. All animals treated with ciprofloxacin and chloramphenicol survived. All animals treated with gentamicin or placebo died. All surviving animals showed evidence of seroconversion. Ciprofloxacin and chloramphenicol were statistically more effective in preventing death than gentamicin or placebo.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=172156Documentos Relacionados
- In vitro effectiveness of azithromycin against doxycycline-resistant and -susceptible strains of Rickettsia tsutsugamushi, etiologic agent of scrub typhus.
- Effect of sublethal gamma radiation on host defenses in experimental scrub typhus.
- In Vitro Response to Chloramphenicol, Tetracycline, Ampicillin, Gentamicin, and Beta-Lactamase Production by Halophilic Vibrios from Human and Environmental Sources
- Host defenses in experimental scrub typhus: effect of chloramphenicol.
- Macrophages in resistance to rickettsial infections: early host defense mechanisms in experimental scrub typhus.