Chromosomal Variation and the Origin of Drug-Resistant Mutants in Mammalian Cell Lines
AUTOR(ES)
Terzi, Mario
RESUMO
Drug-resistant mutants of somatic cell lines fall into two classes: one seems to correspond to classical gene mutation, the other is characterized, albeit transiently, by karyotypic instability, high reversion frequency, and low plating efficiency. An interpretation of the origin of these drug-resistant mutants is offered on the basis of chromosomal variation, which generates variation of the number of copies of each individual chromosome and, consequently, of gene dosage.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=434033Documentos Relacionados
- Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.
- Drug-resistant tuberculosis
- Altered Enzymes in Drug-Resistant Variants of Mammalian Tissue Culture Cells
- Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase.
- Probability Distribution of Drug-Resistant Mutants in Unselected Populations of Mycobacterium tuberculosis
