Chromosome Damage and Early Developmental Arrest Caused by the Rex Element of Drosophila Melanogaster
AUTOR(ES)
Robbins, L. G.
RESUMO
Rex (Ribosomal exchange) is a genetically identified repeated element within the ribosomal DNA (rDNA) of Drosophila melanogaster. Rex has a semidominant maternal effect that promotes exchange between and within rDNA arrays in the first few embryonic mitoses. Several of Rex's genetic properties suggest that its primary effect is rDNA-specific chromosome breakage that is resolved by recombination. We report here that rDNA crossovers are only a small, surviving minority of Rex-induced events. Cytology of embryos produced by Rex-homozygous females reveals obvious chromosome damage in at least a quarter of the embryos within the first three mitotic divisions. More than half of the embryos produced by Rex females die, and the developmental arrest is among the earliest reported for any maternal-effect lethal. The striking lethal phenotype suggests that embryos with early chromosome damage could be particularly fruitful subjects for analysis of the cell biology of early embryos.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1206158Documentos Relacionados
- Specificity of Chromosome Damage Caused by the Rex Element of Drosophila Melanogaster
- Cellular DNA rearrangements and early developmental arrest caused by DNA insertion in transgenic mouse embryos.
- Hsp70 and thermal pretreatment mitigate developmental damage caused by mitotic poisons in Drosophila
- Genetic and Developmental Analysis of Polytene Section 17 of the X Chromosome of Drosophila Melanogaster
- Developmental Genetics of Loci at the Base of the X Chromosome of Drosophila Melanogaster
