Chromosome End Maintenance by Telomerase*
AUTOR(ES)
Osterhage, Jennifer L.
FONTE
American Society for Biochemistry and Molecular Biology
RESUMO
Telomeres, protein-DNA complexes at the ends of eukaryotic linear chromosomes, are essential for genome stability. The accumulation of chromosomal abnormalities in the absence of proper telomere function is implicated in human aging and cancer. Repetitive telomeric sequences are maintained by telomerase, a ribonucleoprotein complex containing a reverse transcriptase subunit, a template RNA, and accessory components. Telomere elongation is regulated at multiple levels, including assembly of the telomerase holoenzyme, recruitment of telomerase to the chromosome terminus, and telomere accessibility. This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2713563Documentos Relacionados
- Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis
- The mouse telomerase RNA 5"-end lies just upstream of the telomerase template sequence.
- ATM and ATR make distinct contributions to chromosome end protection and the maintenance of telomeric DNA in Arabidopsis
- Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo
- Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In Vivo