CI-867, a new semisynthetic penicillin: in vitro studies.

AUTOR(ES)

Weaver, S S

RESUMO

CI-867, a new semisynthetic penicillin, has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. It was especially active against Pseudomonas aeruginosa and as active as mezlocillin and piperacillin against Klebsiella pneumoniae. CI-867 was bactericidal against most organisms. Its activity was greatly reduced when the inoculum was increased from 10(5) to 10(7) organisms per ml.

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