Cl− Secretion in Colonic Epithelial Cells Induced by the Vibrio parahaemolyticus Hemolytic Toxin Related to Thermostable Direct Hemolysin

AUTOR(ES)

Takahashi, Akira

FONTE

American Society for Microbiology

RESUMO

A hemolytic toxin related to thermostable direct hemolysin (TDH), TDH-related hemolysin (TRH), produced by Kanagawa-phenomenon-negative Vibrio parahaemolyticus is suspected of playing an important, but yet-to-be-elucidated role in diarrhea caused by this organism. In cultured human colonic epithelial cells, TRH increases Cl− secretion, followed by elevation of intracellular calcium.

Documentos Relacionados

• Inhibition of hemolytic activity of the thermostable direct hemolysin of Vibrio parahaemolyticus by ganglioside.
• Sequence variation in the thermostable direct hemolysin-related hemolysin (trh) gene of Vibrio parahaemolyticus.
• Demonstration of the cardiotoxicity of the thermostable direct hemolysin (lethal toxin) produced by Vibrio parahaemolyticus.
• A mutant toxin of Vibrio parahaemolyticus thermostable direct hemolysin which has lost hemolytic activity but retains ability to bind to erythrocytes.
• Cytotoxic effect of the thermostable direct hemolysin produced by Vibrio parahaemolyticus on FL cells.