Clearance of Immunoreactive Somatostatin by Perfused Rat Liver
AUTOR(ES)
Sacks, Harold
RESUMO
Other investigators have demonstrated that concentrations of immunoreactive somatostatin (IRS) are higher in blood from the hepatic portal vein or its tributaries than in blood from the hepatic or peripheral systemic veins of man and animals. This suggests that there is hepatic extraction of IRS from the portal system in vivo. In the rat, portal vein plasma IRS is reported to be heterogeneous and to contain, in part, a 1,600 mol wt form of IRS which is immunochemically similar to synthetic somatostatin and not significantly bound to high molecular weight plasma protein. Our study was undertaken to determine directly whether unbound synthetic cyclic somatostatin was cleared by the rat liver perfused through the hepatic portal vein in vitro with a recirculating, plasma-free, erythrocyte-containing perfusate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=370583Documentos Relacionados
- The Handling of Immunoreactive Vasopressin by the Isolated Perfused Rat Kidney
- Uptake of free choline by isolated perfused rat liver.
- The biosynthesis of guanidinosuccinic acid by perfused rat liver.
- Synthesis of clotting factors by the isolated perfused rat liver.
- Production and release of plasminogen by isolated perfused rat liver.