Cleavage of the N-Linked Oligosaccharide from the Surfaces of Chlamydia Species Affects Attachment and Infectivity of the Organisms in Human Epithelial and Endothelial Cells
AUTOR(ES)
Kuo, Cho-chou
FONTE
American Society for Microbiology
RESUMO
Previous studies demonstrated that the high-mannose oligosaccharide N linked to the Chlamydia major outer membrane protein inhibited the attachment and infectivity of the organism. The present study showed that cleavage of the glycan with N-glycanase decreased the attachment and infectivity of chlamydial organisms in human epithelial and endothelial cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=523059Documentos Relacionados
- An N-linked high-mannose type oligosaccharide, expressed at the major outer membrane protein of Chlamydia trachomatis, mediates attachment and infectivity of the microorganism to HeLa cells.
- Defects in the N-Linked Oligosaccharide Biosynthetic Pathway in a Trypanosoma brucei Glycosylation Mutant†
- Regulation of the protein glycosylation pathway in yeast: structural control of N-linked oligosaccharide elongation.
- Role of N-linked glycans of envelope glycoproteins in infectivity of human immunodeficiency virus type 1.
- Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control.